CoQ10 Supplementation for Fibromyalgia Symptoms

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[...] Or a CoQ10 supplementation induces an upregulation of AMPK transcription. It is possible that the action of CoQ10 on AMPK is the main mechanism explaining the beneficial effects of CoQ10 (18). Interest in managing coenzyme Q10 levels Given its various properties, CoQ10 appears to be an interesting compound in the treatment of fibromyalgia. The table below summarizes the interest and effectiveness of CoQ10 in improving clinical signs of fibromyalgia Clinical and molecular parameters Impact on fibromyalgia Interest of Coenzyme Q10 Pain : Hyperalgia Allodynia Central Pain Modulation Disorders: - Decreased pain threshold - Decreased serotonin levels -Increased serotonin levels What inhibits the transmission of pain signals Asthenia: Decrease in muscular effort resistance - Mitochondrial dysfunction: reduced energy production - Decreased serotonin level (Serotonin regulates fatigue) - Increase in ATP production - Increase in serotonin level which regulates fatigue - The CoQ10 improves subjective fatigue and physical performance Sleep - Deep sleep phase not affected - Decreased serotonin levels Increased serotonin levels" What will regulate the wake/sleep cycle Migraine -Oxidative stress with high quantities of compounds resulting from lipid peroxidation - Inflammatory processes with inflammatory compounds producing reactive oxygen species - Overconsumption of CoQ10 - Alteration of pro-inflammatory cytokine levels - Antioxidant that reduces the levels of reactive oxygen species, lipid peroxides - reduces the expression of genes encoding inflammatory compounds Depression - Mitochondrial dysfunction resulting in reduced energy production - Oxidative stress - Low serotonin levels - Increase in ATP production in the mitochondria -Increase in serotonin levels which regulates mood - CoQ10 fights against the effects of oxidative stress In practice Studies have shown that a CoQ10 deficiency could be found in fibromyalgia patients and they could therefore benefit from supplementation to improve certain symptoms such as pain, fatigue, sleep, and depression. [...]

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