Schizophrenia, fatigue, negative symptoms, motivation, depression, cognitive problems, attentional fatigue, emotional deficits, psychopathological disorders
This literature review examines the relationship between fatigue and negative symptoms, particularly motivation, in schizophrenia compared to depression.
[...] We observe the emotional, cognitive, and behavioral impact of fatigue on the negative symptoms of schizophrenia, often manifested by an amotivational syndrome. The differences between the amotivational syndrome in the case of major and/or chronic depression and the manifestations of the amotivational syndrome in people with schizophrenia are identified at the level of chronic fatigue formerly called neurasthenia, but now described under the systems of anhedonia. Given that pharmacological approaches do not always yield significant enough results to manage the negative, primary, and/or secondary symptoms of schizophrenia, and sometimes even depression, it is therefore essential to invest in the relationship between anticipation of pleasure and effort in clinical neuroscientific studies concerning these two psychopathological functions. [...]
[...] Liu, S.K., Hwu, H.-G., and Chen, W.J. (1997). Clinical symptom dimensions and deficits on the Continuous Performance Test in schizophrenia. Schizophrenia Research 25, 211- 219. Llorca, P. (2007). Schizophrenia and prevention. VST - Social life and treatments 47-52. https://doi.org/10.3917/vst.094.0047 Llorca, P. (2018) Depression and schizophrenia. In: Frank Bellivier ed., Actualités on depressive illnesses (pp. [...]
[...] & Décombe, A. (2019). Chapter 6. Cognitive mechanisms at work in negative symptoms. In: Hélène Amieva ed., Neuropsychology in psychiatry (pp. 121-140). Louvain-la-Neuve : De Boeck Supérieur. https://doi-org.merlin.u-picardie.fr/10.3917/dbu.amiev.2019.01.0121 Raffard Rainteau Bayard Laraki Norton Capdevielle D. Assessment of the efficacy of a fatigue management therapy in schizophrenia: study protocol for a randomized, controlled multicentered study (ENERGY). Trials. 2020;21(1):797. [...]
[...] https://doi.org/10.1684/ipe.2019.1901 Leppänen JM. Emotional information processing in mood disorders: a review of behavioral and neuroimaging findings. Curr Opin Psychiatry 19. Jean-Pierre Lindenmayer, Henry Nasrallah, Michael Pucci, Steven James, Leslie Citrome, A systematic review of psychostimulant treatment of negative symptoms of schizophrenia: Challenges and therapeutic opportunitiesSchizophrenia Research,147, p.241-252. H.G. Liddell, R. Robert Scott, Grand dictionnaire de la langue grecque, Thesaurus Linguae Graecae, Internet, www.tlg.uci.edu. E. Littré, Ch. Robin, Dictionnaire de médecine. 12e édition, Paris, Baillière, 1865. [...]
[...] Clinical observation suggests an impact of fatigue on the negative symptoms of schizophrenia through a negative action on motivation and initiative-taking. Does fatigue have an impact on preventing the anticipation of pleasure? The objective here is to propose a theoretical and methodological framework for studies aimed at a better understanding of the impact of fatigue in schizophrenia. Mental fatigue induced by an intense and prolonged task can be studied with regard to its consequences on cognitive performance in schizophrenia, and its executive disorders lead us to think that schizophrenia requires more cognitive effort since the sensation of mental fatigue is exacerbated, i.e. [...]
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