Abstract
The clinical trials performed on humans by the pharmaceutical companies are essentials for the advancement of the knowledge of human health. After the terrible Nazis experimentation during the Second World War, some actions have been taken to protect the participants of the clinical trials. Many laws have been implemented to regulate those trials, because those researches can injure and even induce death of the patients involve in the studies. The Declaration of Helsinki has been written in 1964 and presents the ethical principles of the conduct of human researches. Since then, the declaration has been modified several times. A new ethical problem has emerged in the last decades. More and more clinical trials are made in the developing countries and that created some ethical problems because the economic and social situations in those countries are different than in the developed countries. The laws can not by themselves regulate all the actions of the pharmaceutical companies in the developing countries. Many actions have been implemented to regulate those ethical issues. The governments, the pharmaceutical companies and some local organizations have all took some actions to overcome the problems of the clinical trials in the developing countries.
