Extract
[...] When we are in a context of malnutrition, these vitamin deficiencies are exacerbated by the reduction of food intake. Long-chain polyunsaturated fatty acids (LC-PUFAs), particularly omega-3s such as DHA (docosahexaenoic acid), play a significant role in the brain as they are responsible for the fluidity of neuronal membranes, synaptic plasticity, and the transmission of nerve signals (Cunnane et al., 2020). These lipids are also involved in the synthesis of neuroprotective mediators, such as neuroprotectins, which modulate inflammation and reduce neuronal apoptosis. We observe a deficiency in DHA in AD. This directly impacts the lipid composition of brain membranes. [...]
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[...] (2019a). ESPEN guideline on clinical nutrition and hydration in geriatrics. Clinical Nutrition, 10-47. https://doi.org/10.1016/j.clnu.2018.05.024. Volkert Beck AM, Faxén-Irving Frühwald Hooper Keller Porter Rothenberg Suominen Wirth Chourdakis M. ESPEN guideline on nutrition and hydration in dementia - Update 2024. Clin Nutr Jun;43(6):1599-1626. doi: 10.1016/j.clnu.2024.04.039. Epub 2024 May 8. PMID: 38772068. Wen, Y. (2025a). Nutrition: A non-negligible factor in the pathogenesis and treatment of Alzheimer's disease. Alzheimer's & Dementia. https://doi.org/10.1002/alz.14547. White, L., et al. [...]
[...] B & Silverberg, N. (2018). NIA-AA research framework: Toward a biological definition of Alzheimer's disease. Alzheimer's & Dementia, 535-562. https://doi.org/10.1016/j.jalz.2018.02.018. KKaiser, M. J., Bauer, J. M., Rämsch, C., Uter, W., Guigoz, Y., Cederholm, T., Thomas, D. R., Anthony, P., Charlton, K. E., Maggio, M., Tsai, A. C., Grathwohl, D., Vellas, B. & Sieber, C. C. (2009). Validation of the Mini Nutritional Assessment short-form (MNA-SF): A practical tool for identification of nutritional status. The Journal of Nutrition, Health & Aging, 782-788. [...]
