Biochemistry, RBC Red Blood Cell, metabolism, iron cycle, Erythrocyte Turnover, macrophage function, hemolysis types, AIHA Autoimmune Hemolytic Anemia, bilirubin, haemolysis
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Abstract
Red blood cells are maintained within the normal range thanks to processes that balance their production and destruction. Approximately 5 million red blood cells are destroyed by macrophages every second, while 2 million enter the circulation every second.
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[...] Hemoglobin degradation 5 Heme metabolism in macrophages eClinpath. (n.d.). Retrieved May from https://eclinpath.com/chemistry/iron-metabolism/heme-metabolism/ Hemoglobin oxygenase Biliverdin reductase https://www.grepmed.com/images/11302/metabolism-bilirubin-biochemistry-pathophysiology Types of Red Cell Destruction: Extravascular and Intravascular haemolysis: Extravascular haemolysis: Removal of red cells by cells of the RE system in the spleen and liver. Intravascular haemolysis: The process of breakdown of red cells directly in the circulation. to Extravascular Haemolysis Refer to Hematology clinical principles and applications. Bernadette F Rodak. 4th edition. Saunders Intravascular Haemolysis Refer to Hematology clinical principles and applications. [...]
[...] Saunders The role of Macrophages in recognizing old RBC SciELO - Brazil - Macrophages: key players in erythrocyte turnover Macrophages: key players in erythrocyte turnover process of recycling of hemoglobin - Bing images Mechanism of iron cycle & uptake 1. Iron absorbtion by Enterocyte Iron usage by Erythroblast Iron storage by Hepatocyte Iron recycle by Macrophage. Silva, and Faustino Biochimica et Biophysica Acta (2015): 1347-1359 Formation of splenic bilirubin: Formation of conjugated bilirubin: Types of Auto-immune hemolytic anemia (AIHA) Warm AIHA . Cold AIHA. Paroxysmal Cold Hemoglobinuria (PCH). Drug-Induced Hemolysis. References •Heme metabolism in macrophages eClinpath. (n.d.). Retrieved May from https://eclinpath.com/chemistry/iron-metabolism/heme-metabolism •Higgins JM. Red blood cell population dynamics. Clin Lab Med Mar;35(1):43-57. doi: 10.1016/j.cll.2014.10.002. [...]
[...] Epub 2014 Dec 18. PMID: 25676371; PMCID: PMC4717490. •Thiagarajan Parker CJ, Prchal JT. How Do Red Blood Cells Die? Front Physiol Mar 15;12:655393. doi: 10.3389/fphys.2021.655393. PMID: 33790808; PMCID: PMC8006275. •Hematology clinical principles and applications. Bernadette F Rodak th edition. Saunders •Silva, B. and Faustino, P. (2015) “An overview of molecular basis of iron metabolism regulation and the associated pathologies,” Biochimica et biophysica acta, 1852(7), pp. 1347–1359. doi: 10.1016/j.bbadis.2015.03.011. [...]
