Potential Use of Ulasimang Bato (Peperomia Pellucida) For the Treatment of Psoriasis in The Form Ointment
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Faculty of the College of Nursing and Health Sciences, psoriasis, disease, ulasimang bato, Peperomia Pellucida, treatment, albino mice, skin inflammation
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Psoriasis is an autoimmune disease that causes the skin to be red, flaky, and have crusty patches covered with silvery scales. It can grow anywhere in the body, but mostly appear on the elbows, knees, scalp, and lower back. The patches can be very itchy or sore (National Health System of United Kingdom, 2018). According to an online survey conducted by PsorPhil in 2017 with 645 respondents, 40% of the Filipinos experience moderate to severe psoriasis. Their daily lives are affected: 27% are being bullied, and more than half are stared at in public places. Up to 30% of people with psoriasis will likely develop psoriatic arthritis. It is a condition that combines swollen and sore joints of arthritis with psoriasis (Mayo Clinic, 2019). People with psoriasis produce skin cells faster than other people. Normally, skin cells are replaced every 3 to 4 weeks, but in psoriasis the process only takes 3 to 7 days. It causes build-up of skin cells which results in the patches associated with psoriasis ((National Health System of United Kingdom, 2018). Treatments for psoriasis help to prevent skin cells from developing too rapidly and to remove scales. Creams and ointments (topical therapy), light therapy (phototherapy), oral or injected drugs as well as Vitamin C. Topical treatment includes vitamin D analogues and corticosteroids. For sensitive areas, such as your face or skin folds, and for the treatment of common patches, mild corticosteroid ointments (hydrocortisone) are generally recommended. Vitamin D analogues slow skin cell growth. This can be used alone or with topical corticosteroids. Light therapy is used for moderate to severe psoriasis. It is exposing the skin to natural or artificial light. In cases that these treatments didn't work, oral and injected medications are available (Mayo Clinic, 2020). In the treatment of psoriasis, antioxidants can also help. This avoids damage related to oxidative stress. When levels of disease-triggering free radical molecules and protective antioxidant substances are imbalanced, oxidative stress occurs. Vitamin C, a water-soluble vitamin that also serves as a potent antioxidant, can help reduce the action of free radical psoriasis (Sullivan, 2018). A number of alternative therapies are available including herbal medicine. It is safe and effective in reducing itching and scaling for mild to moderate psoriasis. Herbal medicines help treat various physical and mental conditions. It involves the use of natural and biological products. The World Health Organization reports that 80 percent of the world's population is actually using herbal medicine for some of their health care, or around 4 billion people (Craig Hospital, 2015). A common fleshy shallow rooted herb, ulasiman bato (Peperomia pellucida) has been used as a food item as well as a medicinal herb . The whole plant, either cooked or raw, is edible. In folk herbal medicine, Ulasiman bato has taken its niche, providing health benefits for gout, arthritis and other inflammatory conditions (Medical Health Guide, 2016). No studies has yet to be conducted if ulasiman bato can be used for the treatment of psoriasis. But this plant is also known to have antioxidant properties for which is also used for treating the condition. This study aims to determine potential use of ulasiman bato to treat psoriasis. The leaves of the plant will be used in making the ointment. It will be extracted by decoction method. The extract will be used to make an ointment by mixing it with wool fat, hard paraffin, cetostearyl alcohol, and white soft paraffin.
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[...] As a result, the fibrinolytic activity appears to be inversely related to the iron concentration. In contrast to the results of the fibrinolytic test, P. pellucida Kunth was found to have thrombolytic activity in an in vitro test conducted by Zubair et al. (2015). In comparison to the standard medicine Streptokinase 65 percent, ethanol soluble fractions of P. pellucida Kunth demonstrated highest activity of 50.65 percent clot lysis. Zubair et al. tested the antidiarrheal properties of an ethanolic extract of P. [...]
[...] L., Gumber, S., Wang, H., Moore, R. H., & Taylor, D. K. (2019). Evaluation of 4 Presurgical Skin Preparation Methods in Mice. Journal of the American Association for Laboratory Animal Science : JAALAS, 58(1), 71-77. https://doi.org/10.30802/AALAS-JAALAS-18-000047 Spruce L. Back to Basics: Surgical Skin Antisepsis. AORN J Jan;103(1):96-100; quiz 101-2. doi: 10.1016/j.aorn.2015.11.002. PMID: 26746032. Hamza Tohid Maibach H. Shaving effects on percutaneous penetration: clinical implications. Cutan Ocul Toxicol. 2015;34(4):335-43. doi: 10.3109/15569527.2014.966109. [...]
[...] It is estimated that a significant population of juvenile guttate psoriasis cases are preceded by streptococcal infections (Campalani & Barker, 2005). The outburst of psoriasis was not associated with gender, but primarily with the climate which is dry cold weather of the environment. There are 5 existing types of psoriasis. The most common type of psoriasis is called psoriasis vulgaris. It characterized by red papules or rash, then, expands gradually or merged into a flake and the surface is covered with multi-layer gray or silver white scales. [...]
[...] (2013) used a drill hole model of damage to assess the plant's antiosteoporosis activity. An ethanol extract can stimulate bone regeneration at the fracture site, according to this test. The extract can promote bone mineral deposition, improve bone microarchitecture, and raise osteogenic gene expression, including mRNA levels of bone morphogenetic protein-2, type-1 collagen, and osteocalcin, by up to 25-30 times more than the negative control at a dose of 200 mg/kg. An ethanolic extract of Peperomia pellucida Kunth herbs at a concentration of 100 mg/kg exhibited a preventative effect for osteoporosis in a recent study employing an ovariectomy-induced osteoporotic rat model. [...]
[...] Topical treatments include creams, ointment, and lotions. (Fallen et al., 2013). According to MacGill (2018), psoriasis is a long-term disease of the skin that has no cure, although doctors can help manage symptoms. Some people are looking to use alternative treatments, such as essential oils, to treat the disease at home. Essential oils are concentrated plant extracts, some of which claim to be effective alternative treatments under certain conditions. Different plants have numerous impacts. However, very few studies have been performed on the efficacy of essential oils as alternative therapy for psoriasis. [...]
